mutually exclusive events

Vaske and colleagues have used a factor graph belief propagation algorithm to integrate copy number and expression data to score curated pathways. For example, the outcomes 1 and 4 of a single roll of a are mutually exclusive both cannot happen at the same time but not collectively exhaustive there are other possible outcomes; 2,3,5,6.

Mutual exclusivity is often discussed as one of three main lexical constraints, or , that are believed to play major roles in word learning, the other two being the and constraints. New York: Cambridge University Press.

Mutual Exclusivity - They are then asked to choose which object is the dax. For example, BRCA1 and CCNE1 share 12 common interactors, 10 of which are involved in cell cycle regulation, including CDK1, CDK2, CCNA2, and BARD1.

BENNETT as Remington Affiliates. THE PARTIES HERETO ENTER THIS AGREEMENT on the basis of the following facts, understandings and intentions: A. The Remington Parties plan to continue to engage in various aspects of development, renovation, management and operation of Hotel Properties. The REIT has undertaken, or will concurrently with its initial public offering, undertake to acquire, develop, invest in, or purchase or make loans with respect to Hotel Properties that meet the REIT's investment criteria. The REIT Parties desire to benefit from the hotel development and management experience of the Remington Parties and have agreed to engage Manager in connection with certain investment opportunities subject to the ability of the Independent Directors of the REIT to unanimously vote not to engage Manager ; provided, the Remington Parties agree to grant the REIT Parties a first right of refusal with respect to any Remington Transaction that any of the Remington Parties resource or identify. NOW, THEREFORE, IN CONSIDERATION of the mutual covenants and promises of the parties hereto, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 1. All terms used in this Agreement but not defined herein shall have the meanings as set forth on EXHIBIT B attached hereto and incorporated herein for all purposes applicable to both the singular and plural forms of the terms defined. Notwithstanding the foregoing, the Initial Term shall automatically be extended at the expiration of the Initial Term with respect to the Remington Exclusivity Rights or the REIT Exclusivity Rights, or both, as applicable , on the same terms and conditions contained herein, for each of three 3 successive periods of seven 7 Fiscal Years each and one final period of four 4 years; provided, however, that at the time of the expiration of the Initial Term or extension term, as applicable, a Termination Event with respect to the entirety of this Agreement does not then exist. Subject to SECTION 8 b below, upon termination of the entirety of this Agreement, the Remington Parties and the REIT Parties shall have no further obligations to one another pursuant to this Agreement, except for any indemnification obligations contained herein, which shall survive such termination. Upon the occurrence of any of the following events, the Remington Parties acting through Manager may, at their election exercised in their sole and absolute discretion and upon written notice to the REIT Parties, terminate the REIT Exclusivity Rights: i Montgomery J. Bennett 1 is removed without Cause, 2 is not re-appointed as chief executive officer of the REIT, or 3 resigns as chief executive officer of the REIT for Good Reason, or the Employment Agreement is not renewed, or there is a Change in Control; but with respect to all of the foregoing, excluding in connection with the death of Montgomery J. Bennett; ii Archie Bennett, Jr. Bennett, if the REIT Parties have not already terminated the Remington Exclusivity Rights with respect to the REIT Termination Events set forth in SECTION 3 b ii OR iii below; and iv Subject to each party's obligation to act in good faith, if Montgomery J. Upon the REIT Parties' receipt of written notice of termination of the REIT Exclusivity Rights from the Remington Parties, the REIT Exclusivity Rights set forth in this Agreement shall terminate; however, all other terms and provisions of this Agreement shall remain in full force and effect, including the Remington Exclusivity Rights, until this Agreement expires or is otherwise terminated as permitted under this Agreement. Bennett resigns as chief executive officer of the REIT without Good Reason; iii If Montgomery J. Bennett's Employment Agreement is terminated for Cause; iv Any one of the Remington Parties ceases to be controlled by Archie Bennett, Jr. Upon the Remington Parties' receipt of written notice of termination of the Remington Exclusivity Rights from the REIT Parties, the Remington Exclusivity Rights set forth in this Agreement shall terminate; however, all other terms and provisions of this Agreement shall remain in full force and effect, including the REIT Exclusivity Rights, until this Agreement expires or is otherwise terminated as permitted under this Agreement. Such Remington Notice shall be delivered to the REIT Parties with a copy to the Independent Directors , as soon as reasonably practical after the opportunity of the Remington Transaction is identified for any of the Remington Affiliates. If the REIT Parties fail to deliver a REIT ROFR Notice within the REIT ROFR Period or by REIT ROFR Notice reject or decline to purchase and assume the Remington Transaction, or the applicable REIT Affiliate fails to timely prepare and execute the proper REIT Transaction Documents with respect to the Remington Transaction, then the REIT ROFR shall lapse. In such event, the applicable Remington Affiliate shall be entitled to proceed with the Remington Transaction described in the Remington Notice on materially the same terms and conditions as outlined therein within the time period established therein and in accordance with the underlying REIT Transaction Documents, subject to reasonable extensions of the closing date. If the applicable Remington Affiliate fails to consummate the Remington Transaction on materially the same terms and conditions, or if the terms and conditions materially differ, then the Remington Parties hereby grant on behalf of themselves and the applicable Remington Affiliate to the REIT Parties the exclusive first right of refusal to purchase and assume the rights and obligations of the applicable Remington Affiliate with respect to such Remington Transaction on the changed terms and conditions and in connection therewith shall deliver to the REIT Parties a new Remington Notice subject to the same time requirements for review and exercise as set forth in this Agreement. During the REIT ROFR Period with respect to each Remington Transaction and the related Hotel Property, the Remington Parties shall deliver to the REIT Parties upon the written request of the REIT Parties, from time to time and to the extent available, i any and all documents, correspondence and reports, including, without limitation, due diligence information including, property condition reports, surveys, environmental reports , information and documents bearing on contracts, litigation and such other matters, and title and lien information; ii any notices of non-compliance with applicable laws bearing on such Hotel Property; iii quarterly financial information with respect to such Hotel Property showing hotel revenues and hotel operating expenses; and iv such other information relating to the Hotel Property or the Remington Transaction as reasonably requested by the REIT Parties. Reimbursement to the Remington Parties of the Reimbursement Amount shall be the sole payment to the applicable Remington Affiliate with regard to a Remington Transaction. The Remington Parties shall not receive any finder's fee, brokerage fee, development fee, or other commissions or compensation with regard to any Remington Transaction. The REIT Parties may engage a third party and not Manager or an Affiliate of Manager to provide the services in connection with the REIT Transaction if the Independent Directors unanimously vote not to engage Manager in connection with said REIT Transaction. In the event that a REIT Transaction for which Manager has been engaged relates to the management and operation of a Hotel Property, the terms and conditions of the management, operation and any construction, renovations, improvements, refurbishments, or other services, such as purchasing, interior design, freight management, and construction management, to be undertaken with respect to such Hotel Property during the term of such management and operation, including the amount of any management, incentive, project or other service fees shall be either pursuant to the terms and conditions of the Master Management Agreement and the Master Management Agreement shall be amended accordingly to include such Hotel Property , or pursuant to a management agreement with a subsidiary of Manager substantially in form of the Master Management Agreement. In the event that a REIT Transaction relates to the development and construction of a Hotel Property, then the terms and conditions of any such development and construction, including the project oversight and developer management fees, shall be pursuant to the terms set forth in that certain form of Development Agreement attached hereto as EXHIBIT C. Notwithstanding anything contained in this Agreement to the contrary, the REIT Parties' rights under SECTION 4 do not extend to the Excluded Remington Transactions and the Remington Parties' rights under SECTION 4 c or SECTION 5 do not extend to the Excluded REIT Transactions. Each party hereto agrees to give written notice to the other party of any Excluded REIT Transaction or Excluded Remington Transaction, as applicable, describing said transaction with reasonable detail. The Remington Parties shall indemnify and hold the REIT Affiliates and their respective agents, principals, shareholders, partners, members, officers, directors, attorneys and employees harmless from and against all liabilities, losses, claims, damages, costs and expenses including, but not limited to, reasonable attorneys' fees and expenses that may be incurred by or asserted against any such party and that arise from i the fraud, willful misconduct or gross negligence of any of the Remington Affiliates, ii the breach by the Remington Affiliates of any provision of this Agreement, or iii the breach by the Remington Affiliates of any Remington Transaction Documents first occurring prior to the date of the assumption of same by any of the REIT Affiliates. The REIT Parties shall promptly provide the Remington Parties with written notice of any claim or suit brought against any of them by a third party which might result in such indemnification. Except as set forth in SECTION 7 a herein above, the REIT Parties shall indemnify and hold the Remington Affiliates and their respective agents, principals, shareholders, partners, members, officers, directors, attorneys and employees harmless from and against all liabilities, losses, claims, damages, costs and expenses including, but not limited to, reasonable attorneys' fees and expenses that may be incurred by or asserted against any such party and that arise from i the fraud, willful misconduct or gross negligence of the REIT Affiliates other than any Remington Affiliate , or ii the breach by the REIT Affiliates of any provision of this Agreement other than any Remington Affiliate. The Remington Parties shall promptly provide the REIT Parties with written notice of any claim or suit brought against any of them by a third party which might result in such indemnification. If the Indemnifying Party gives such notice, i such defense shall be conducted by counsel selected by the Indemnifying Party and approved by the indemnified party, such approval not to be unreasonably withheld or delayed provided, however, that the indemnified party's approval shall not be required with respect to counsel designated by the Indemnifying Party's insurer ; ii so long as the Indemnifying Party is conducting such defense with reasonable diligence, the Indemnifying Party shall have the right to -7- control said defense and shall not be required to pay the fees or disbursements of any counsel engaged by the indemnified party for services rendered after the Indemnifying Party has given the written notice provided for above to the indemnified party, except if there is a conflict of interest between the parties with respect to such claim or defense; and iii the Indemnifying Party shall have the right, without the consent of the indemnified party, to settle such claim, provided that such settlement involves only the payment of money, the Indemnifying Party pays all amounts due in connection with or by reason of such settlement and, as part thereof, the indemnified party is unconditionally released from all liability in respect of such claim. The indemnified party shall have the right to participate in the defense of such claim being defended by the Indemnifying Party at the expense of the indemnified party, but the Indemnifying Party shall have the right to control such defense other than in the event of a conflict of interest between the parties with respect to such claim or defense. In no event shall i the indemnified party settle any claim without the consent of the Indemnifying Party so long as the Indemnifying Party is conducting the defense thereof in accordance with this Agreement; or ii if a claim is covered by the Indemnifying Party's liability insurance, take or omit to take any action which would cause the insurer not to defend such claim or to disclaim liability in respect thereof. EVENTS OF DEFAULT; CONSEQUENCES; REMEDIES. Upon the occurrence of any Event of Default, the non-defaulting party may, at its election, give the defaulting party written notice of intention to terminate this Agreement after the expiration of any applicable grace or cure period provided in SECTION 8 a above , and upon the expiration of thirty 30 days from the date of such notice, this Agreement shall terminate and the non-defaulting party shall be entitled to pursue any and all rights and remedies available, at law or in equity, to the non-defaulting party under this Agreement including any indemnity obligations which shall survive this Agreement or under applicable law. Bennett To the REIT Parties: Ashford Hospitality Trust, Inc. Ashford Hospitality Limited Partnership 14180 Dallas Parkway 7th Floor Dallas, Texas 75254 Attn: Chief Financial Officer -9- with a copy to: Ashford Hospitality Trust, Inc. Ashford Hospitality Limited Partnership 14180 Dallas Parkway 7th Floor Dallas, Texas 75254 Attn: Legal Department with a copy to: Ashford Hospitality Trust, Inc. No amendment, modification or supplement to this Agreement shall be binding on any of the parties hereto unless it is in writing and signed by the parties in interest at the time of the modification, and further provided any such modification is approved by a majority of the Independent Directors. Neither this Agreement nor any rights or obligations hereunder shall be assignable by a party to this Agreement without the prior, express written consent of the other party. This Agreement and all of the provisions hereof shall be binding upon and inure to the benefit of the parties to this Agreement and their respective successors and permitted assigns. This Agreement is solely for the benefit of the parties to this Agreement and should not be deemed to confer upon third parties any remedy, claim, liability, reimbursement, claims or action or other right in excess of those existing without reference to this Agreement. Titles and headings to paragraphs and sections in this Agreement are inserted for the convenience of reference only and are not intended to be a part of or to affect the meaning or interpretation of this Agreement. Any provision of this Agreement that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof. Any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. Without prejudice to any rights or remedies otherwise available to any party to this Agreement, each party hereto acknowledges that damages would not be an adequate remedy for any breach of the provisions of this Agreement and agrees that the obligations of the parties hereunder shall be specifically enforceable. Time shall be of the essence as to each and every provision of this Agreement. The parties to this Agreement will execute and deliver or cause the execution and delivery of such further instruments and documents and will take such -10- other actions as any other party to the Agreement may reasonably request in order to effectuate the purpose of this Agreement and to carry out the terms hereof. This Agreement, and the other agreements and documents referred to herein, shall constitute the entire agreement between the parties with respect to the subject matter thereof and shall supersede all previous negotiations, commitments and writings with respect to such subject matter. THIS AGREEMENT AND ITS INTERPRETATION, VALIDITY AND PERFORMANCE SHALL BE GOVERNED BY THE LAWS OF THE STATE OF MARYLAND, WITHOUT REGARD TO ITS CONFLICTS OF INTEREST PRINCIPLES. IN THE EVENT ANY COURT OF LAW OF APPROPRIATE JUDICIAL AUTHORITY SHALL HOLD OR DECLARE THAT THE LAW OF ANOTHER JURISDICTION IS APPLICABLE, THIS AGREEMENT SHALL REMAIN ENFORCEABLE UNDER THE LAWS OF THE APPROPRIATE JURISDICTION. PARTNERSHIP: ASHFORD HOSPITALITY LIMITED PARTNERSHIP, a Delaware limited partnership By: Ashford GP Limited Liability Company, a Delaware limited liability company, its general partner By: Ashford Hospitality Trust, Inc. Embassy Suites 14021 Noel Road Remington Suites Dallas, 1998 150 Dallas, TX L. Embassy Suites 2339 Centreville Road Remington Suites Dulles, 1998 150 Herndon, VA 20171-3021 L. Embassy Suites 4315 Swenson Street Remington Suites Las 1999 220 Las Vegas, NV Vegas, L. Radisson Hotel 1730 North Ocean Ave. Remington Long Island 1989 188 Holtsville, NY Hotel, L. Bennett dated on or about the date of this Agreement and executed with the REIT as employer. The Reimbursement Amount shall be calculated by the Remington Parties and set forth in a certificate delivered to the REIT Parties and certified as true and correct by the Remington Parties. The Reimbursement Amount shall not include any finder's fee, brokerage fee, development fee, or other compensation paid to the Remington Affiliates.

After idea pruning, the final network for HRN1 consists of 9566 genes and 46,608 edges, and HRN2 consists of 9115 genes and 175,585 edges. Step 4: Assess each clique for mutual exclusivity In Step 4, MEMo determines whether each clique identified in Step 3 exhibits a pattern of mutually exclusive genomic alterations, and whether this con is unlikely to be observed by chance. In contrast, RB1 deletions and Mutual exclusivity amplifications accelerate the cell cycle, resulting in defective S-phase progression, increased chromosome breakage, and increased genomic instability. If the child responds ambiguously e. Prospecting and the Myth of Mutual Exclusivity Mutual exclusivity means that I can have either A, or I can have B, but I cannot have both A and B. What other prospecting methods are being used by your peer group. This means that just by speaking naturally and introducing children to a wide range of objects and experiences, adults enable children to learn new vocabulary. This may include content you provide for publication. Copy number analysis identifies novel custodes between genomic loci in ovarian cancer.